Determination of optical purity of 3,5-dimethoxybenzoyl-leucine diethylamide by chiral chromatography and 1H and 13C NMR spectroscopy |
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Authors: | Heo Kyu Sung Hyun Myung Ho Cho Yoon Jae Ryoo Jae Jeong |
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Institution: | Analytical Technology Team, LG Display, Gumi, Korea. |
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Abstract: | (R)-N-3,5-dinitrobenzoyl (DNB) leucine derived chiral selector was used as an HPLC chiral stationary phase for the resolution of various racemic amino acids derivatives. In this study, determination of optical purity of an amino acid derivative was performed by chiral high performance liquid chromatography and 1H and 13C NMR spectroscopy by using the DNB leucine derived chiral selector. The accuracy and precision of each optical purity value are calculated and the data are compared to each other. |
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Keywords: | DNB phenylglycinol chiral selector HPLC optical purity 1H NMR 13C NMR |
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