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Genomewide clonal analysis of lethal mutations in the Drosophila melanogaster eye: comparison of the X chromosome and autosomes |
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| Authors: | Call Gerald B Olson John M Chen Jiong Villarasa Nikki Ngo Kathy T Yabroff Allison M Cokus Shawn Pellegrini Matteo Bibikova Elena Bui Chris Cespedes Albert Chan Cheryl Chan Stacy Cheema Amrita K Chhabra Akanksha Chitsazzadeh Vida Do Minh-Tu Fang Q Angela Folick Andrew Goodstein Gelsey L Huang Cheng R Hung Tony Kim Eunha Kim William Kim Yulee Kohan Emil Kuoy Edward Kwak Robert Lee Eric Lee JiEun Lin Henry Liu H-C Angela Moroz Tatiana Prasad Tharani Prashad Sacha L Patananan Alexander N Rangel Alma Rosselli Desiree Sidhu Sohrab Sitz Daniel Taber Chelsea E Tan Jingwen Topp Kasey Tran PhuongThao |
| Institution: | Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095, USA. |
| Abstract: | Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development as that found on the autosomes. |
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