Manganese superoxide dismutase in pathogenic fungi: An issue with pathophysiological and phylogenetic involvements |
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| Authors: | Emilie Fréalle Christophe Noël Eric Viscogliosi Daniel Camus Eduardo Dei-Cas Laurence Delhaes |
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| Institution: | 1. ECOPA (EA 3609), Lille Pasteur Institute, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex, France;2. Parasitology-Mycology Service (EA 3609), Lille 2 University Hospital Center, 59045 Lille, France;3. Inserm U547, IFR17, Lille Pasteur Institute, 59019 Lille Cedex, France;1. Department of Internal Medicine, Infectious Diseases Division, Washington University, School of Medicine Campus Box 8051, 660 S. Euclid Ave., St. Louis Missouri 63110-1093 USA. Tel.: +1 40 61 35 18; fax: +1 40 61 34 19;2. Laboratorio de Inmunología de Hongos, Depto. de Microbiología y Parasitología, Facultad de Medicina, UNAM Cd. Universitaria 04510 México, D.F. Tel.:/fax: +52 555 56-23-24-62;3. Lille-2 University Hospital Center and Ecology of Parasitism, Institute Pasteur of Lille 1, rue du Prof-Calmette - BP245 59019 Lille cedex (France) Tel.: +33 3 20 87 71 55; fax: +33 3 20 87 72 24 |
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| Abstract: | Manganese-containing superoxide dismutases (MnSODs) are ubiquitous metalloenzymes involved in cell defence against endogenous and exogenous reactive oxygen species. In fungi, using this essential enzyme for phylogenetic analysis of Pneumocystis and Ganoderma genera, and of species selected among Ascomycota, Basidiomycota and Zygomycota, provided interesting results in taxonomy and evolution. The role of mitochondrial and cytosolic MnSODs was explored in some pathogenic Basidiomycota yeasts (Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. gattii, Malassezia sympodialis), Ascomycota filamentous fungi (Aspergillus fumigatus), and Ascomycota yeasts (Candida albicans). MnSOD-based phylogenetic and pathogenic data are confronted in order to evaluate the roles of fungal MnSODs in pathophysiological mechanisms. |
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