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Discovery of novel PTP1b inhibitors
Authors:Ockey Denise A  Gadek Thomas R
Affiliation:Genentech, Inc., Department of Bioorganic Chemistry, One DNA Way, South San Francisco, CA 94080, USA. ockey@speakeasy.net
Abstract:
A small library of 19 compounds was designed based on unique structural features of PTP1b. Utilizing electrospray ionization mass spectrometry (ESI-MS) to provide binding information about complexes of enzyme and small molecule ligands, two classes of lead compounds were discovered.
Keywords:
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