Discovery of novel PTP1b inhibitors |
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Authors: | Ockey Denise A Gadek Thomas R |
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Affiliation: | Genentech, Inc., Department of Bioorganic Chemistry, One DNA Way, South San Francisco, CA 94080, USA. ockey@speakeasy.net |
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Abstract: | ![]() A small library of 19 compounds was designed based on unique structural features of PTP1b. Utilizing electrospray ionization mass spectrometry (ESI-MS) to provide binding information about complexes of enzyme and small molecule ligands, two classes of lead compounds were discovered. |
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