Symbiotic relations of human and microorganisms

Symbiosis has been considered as a biological basis of infectious process. Particular attention was paid to the change of paradigm in symbiology and the appearance of a novel term--associative symbiosis. Principal structural-and-functional elements of associative symbiosis were estimated, and 3 vectors of infectious process such as i) host--normaflora, ii) host--associants, iii) associants--indigious microflora (microsymbiocenosis) were isolated. Functions of microsymbionts that determine colonization resistance of the host, and the formation of dysbioses and pathobiocenoses were reviewed. Phenomenon of microbial recognition for "self-nonself" has been revealed on the basis of opportunistic (increase/decrease) interactions on growth persistent (including biofilm formation) peculiarities of a pair "dominant-associant" under conditions of microsymbiocenosis in human. Material was presented to characterize the role of intercellular interactions of symbionts at the level of prokaryotes, pro-eukaryotes under conditions of infectious pathology.