Addressing the use of PDIF-CN2 molecules in the development of n-type organic field-effect transistors for biosensing applications |
| |
Authors: | M Barra D Viggiano P Ambrosino F Bloisi FV Di Girolamo MV Soldovieri M Taglialatela A Cassinese |
| |
Institution: | 1. CNR-SPIN and Department of Physics Science, University of Naples Federico II, Naples, Italy;2. Medicine and Health Sciences Department, University of Molise, Campobasso, Italy |
| |
Abstract: | BackgroundThere is no doubt that future discoveries in the field of biochemistry will depend on the implementation of novel biosensing techniques, able to record biophysiological events with minimal biological interference. In this respect, organic electronics may represent an important new tool for the analysis of structures ranging from single molecules up to cellular events. Specifically, organic field-effect transistors (OFET) are potentially powerful devices for the real-time detection/transduction of bio-signals. Despite this interest, up to date, the experimental data useful to support the development of OFET-based biosensors are still few and, in particular, n-type (electron-transporting) devices, being fundamental to develop highly-performing circuits, have been scarcely investigated.MethodsHere, films of N,N′-1H,1H-perfluorobutyldicyanoperylene-carboxydi-imide (PDIF-CN2) molecules, a recently-introduced and very promising n-type semiconductor, have been evaporated on glass and silicon dioxide substrates to test the biocompatibility of this compound and its capability to stay electrically-active even in liquid environments.ResultsWe found that PDIF-CN2 transistors can work steadily in water for several hours. Biocompatibility tests, based on in-vitro cell cultivation, remark the need to functionalize the PDIF-CN2 hydrophobic surface by extra-coating layers (i.e. poly-l-lysine) to favor the growth of confluent cellular populations.ConclusionsOur experimental data demonstrate that PDIF-CN2 compound is an interesting organic semiconductor to develop electronic devices to be used in the biological field.General significanceThis work contributes to define a possible strategy for the fabrication of low-cost and flexible biosensors, based on complex organic complementary metal-oxide-semiconductor (CMOS) circuitry including both p- (hole-transporting) and n-type transistors. This article is part of a Special Issue entitled Organic Bioelectronics—Novel Applications in Biomedicine. |
| |
Keywords: | OFET organic field-effect transistors CMOS complementary metal-oxide-semiconductor LUMO lowest unoccupied molecular orbitals PDIF-CN2 N N&prime -1H 1H-perfluorobutyldicyanoperylene-carboxydi-imide PDI8-CN2 N N&prime -bis(n-octyl)-1 6-dicyanoperylene-3 4:9 10-bis(dicarboximide) CHO Chinese hamster ovary DMEM Dulbecco's modified medium SiO2 silicon dioxide HMDS hexamethylsiloxane FBS fetal bovine serum FDA fluorescein diacetate PI propidium iodide PBS phosphate buffered saline MOSFET metal-oxide-semiconductor field-effect-transistors LSD least significant difference AFM atomic force microscopy |
本文献已被 ScienceDirect 等数据库收录! |
|