Research into the (Cost-) effectiveness of the ketogenic diet among children and adolescents with intractable epilepsy: design of a randomized controlled trial |
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| Authors: | Reina JA de Kinderen,Danielle AJE Lambrechts,Debby Postulart,Alfons GH Kessels,Jos GM Hendriksen,Albert P Aldenkamp,Marian HJM Majoie |
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| Affiliation: | (1) Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands;(2) Department of Research and Development, Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands;(3) Department of Neurology, Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands;(4) Department of Clinical Epidemiology and Medical Technology Assessment, University Hospital Maastricht, Maastricht, The Netherlands;(5) Department of Behavioral Sciences, Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands;(6) Department of Neurology, Maastricht University Medical Centre, Maastricht, The Netherlands;(7) Research School of Mental Health & Neuroscience, Maastricht University, Maastricht, The Netherlands |
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| Abstract: | Background Epilepsy is a neurological disorder, characterized by recurrent unprovoked seizures which have a high impact on the individual as well as on society as a whole. In addition to the economic burden, epilepsy imposes a substantial burden on the patients and their surroundings. Patients with uncontrolled epilepsy depend heavily on informal care and on health care professionals. About 30% of patients suffer from drug-resistant epilepsy. The ketogenic diet can be a treatment of last resort, especially for children. The beneficial effect of the ketogenic diet has been proven, but information is lacking about its cost-effectiveness. In the current study we will evaluate the (cost-) effectiveness of the ketogenic diet in children and adolescents with intractable epilepsy. |
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