Cost-effectiveness of homograft heart valve replacement surgery: an introductory study |
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Authors: | Mohsen Yaghoubi Hamid Reza Aghayan Babak Arjmand Seyed Hassan Emami-Razavi |
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Institution: | (1) School of Management and Medical Information Science, Iran University of Medical Sciences, Tehran, Iran;(2) Iranian Tissue Bank, Tehran University of Medical Sciences, Tehran, Iran;(3) Endocrine and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran;(4) Brain and Spinal Injury Repair Reseach Center, Tehran University of Medical Sciences, Tehran, Iran; |
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Abstract: | The clinical effectiveness of heart valve replacement surgery has been well documented. Mechanical and homograft valves are
used routinely for replacement of damaged heart valves. Homograft valves are produced in our country but we import the mechanical
valves. To our knowledge the cost-effectiveness of homograft valve has not been assessed. The objective of the present study
was to compare the cost-effectiveness of homograft valve replacement with mechanical valve replacement surgery. Our samples
were selected from 200 patients that underwent homograft and mechanical heart valve replacement surgery in Imam-Khomeini hospital
(2000–2005). In each group we enrolled 30 patients. Quality of life was measured using the SF-36 questionnaire and utility
was measured in quality-adjusted life years (QALYs). For each group we calculated the price of heart valve and hospitalization
charges. Finally the cost-effectiveness of each treatment modalities were summarized as costs per QALYs gained. Forty male
and twenty female participated in the study. The mean score of quality of life was 66.06 (SD = 9.22) in homograft group and
57.85 (SD = 11.30) in mechanical group (P < 0.05). The mean QALYs gained in homograft group was 0.67 more than mechanical group. The incremental cost-effectiveness
ratio (ICER) revealed a cost savings of 1,067 US$ for each QALY gained in homograft group. Despite limitation of this introductory
study, we concluded that homograft valve replacement was more effective and less expensive than mechanical valve. These findings
can encourage healthcare managers and policy makers to support the production of homograft valves and allocate more recourse
for developing such activities. |
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