Role of arylalkylamine <Emphasis Type="Italic">N</Emphasis>-acetyltransferase in regulation of biogenic amines levels by gonadotropins in <Emphasis Type="Italic">Drosophila</Emphasis> |
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| Authors: | I Yu Rauschenbach N V Adonyeva A A Alekseev N A Chentsova N E Gruntenko |
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| Institution: | (1) Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Lavrentjev ave., 10, Novosibirsk, 630090, Russia;(2) Institute of Chemical Kinetics and Combustion, Siberian Division of Russian Academy of Sciences, Novosibirsk, 630090, Russia |
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| Abstract: | The effect of 20-hydroxyecdysone (20E) and the juvenile hormone (JH) on the activity of the arylalkylamine N-acetyltransferase (AANAT) was studied in young females of wild-type D. virilis and D. melanogaster. 20E feeding of the flies led to a decrease in AANAT activity in both species when dopamine (DA) was used as substrate, but
did not affect the enzyme activity when octopamine (OA) was used as substrate. JH application increased AANAT activity with
DA as substrate in both species, but did not change it with OA as substrate. AANAT activity was also measured in young females
of a JH-deficient strain of D. melanogaster, apterous
56f
. A decrease in the enzyme activity was observed in the mutant females as compared to wild-type. Mechanisms of regulation
of DA level by gonadotropins in Drosophila are discussed. |
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| Keywords: | Drosophila Arylalkylamine N-acetyltransferase Dopamine Octopamine Juvenile hormone 20-Hydroxyecdysone |
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