Synthesis and SAR studies of potent imidazopyridine anticoccidial agents |
| |
| Authors: | Liang Gui-Bai Qian Xiaoxia Feng Dennis Fisher Michael Brown Christine M Gurnett Anne Leavitt Penny Sue Liberator Paul A Misura Andrew S Tamas Tamas Schmatz Dennis M Wyvratt Matthew Biftu Tesfaye |
| |
| Institution: | Merck Research Laboratories, Department of Medicinal Chemistry, Merck and Co., Inc., PO Box 2000, Rahway, NJ 07065, USA. gui-bai_liang@merck.com |
| |
| Abstract: | Diaryl imidazo1,2-a]pyridine derivatives, such as 6a and 7i, have been synthesized and found to be potent inhibitors of parasite PKG activity. The most potent compounds are the 7-isopropylaminomethyl analog 6a and 2-isopropylamino analog 7i. These compounds are also fully active in in vivo assay as anticoccidial agents at 25 ppm in feed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
