| 真菌来源的药用天然产物 |
| |
| 引用本文： | 杜凤翔,郭晓媚,杨琳,高书山.真菌来源的药用天然产物[J].微生物学通报,2019,46(9):2411-2418. |
| |
| 作者姓名： | 杜凤翔 郭晓媚 杨琳 高书山 |
| |
| 作者单位： | 1 北京联合大学生物化学工程学院 生物质资源化利用北京市重点实验室 北京 100023,1 北京联合大学生物化学工程学院 生物质资源化利用北京市重点实验室 北京 100023,1 北京联合大学生物化学工程学院 生物质资源化利用北京市重点实验室 北京 100023,2 中国科学院微生物研究所 北京 100101 |
| |
| 基金项目： | 北京联合大学人才强校优选计划“百优计划”；北京高等学校高水平人才交叉培养“实培计划”大学生科研训练计划深化项目；启明星科研训练计划成果；国家自然科学基金面上项目(31872614) |
| |
| 摘 要： | 天然产物及其衍生物，包括基于天然产物药效基团结构设计的化合物，约占临床药物的50%以上。几个世纪以来，真菌天然产物的药用价值闻名于世。无论从市场前景还是人道主义角度，真菌来源的小分子药物都具有极高的应用价值。本篇综述总结了真菌天然产物在临床上的应用，并以他汀类药物的研发历程揭示了真菌来源小分子是化学合成药物研发的重要灵感源泉。本篇综述涵盖了真菌来源的药物小分子，包括天然药物、相关衍生物以及结构修饰药物。
|
| 关 键 词： | 真菌，天然产物，药物 |
Natural medicinal products of fungal origin |
| |
| DU Feng-Xiang,GUO Xiao-Mei,YANG Lin and GAO Shu-Shan.Natural medicinal products of fungal origin[J].Microbiology,2019,46(9):2411-2418. |
| |
| Authors: | DU Feng-Xiang GUO Xiao-Mei YANG Lin and GAO Shu-Shan |
| |
| Institution: | 1 Biochemical Engineering College, Beijing Union University, Beijing Key Laboratory of Biomass Waste Resource Utilization, Beijing 100023, China,1 Biochemical Engineering College, Beijing Union University, Beijing Key Laboratory of Biomass Waste Resource Utilization, Beijing 100023, China,1 Biochemical Engineering College, Beijing Union University, Beijing Key Laboratory of Biomass Waste Resource Utilization, Beijing 100023, China and 2 Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China |
| |
| Abstract: | Natural products and their derivatives, including the compounds designed based on the structure of natural product pharmacophores, account for more than 50% of approved drugs. The medicinal value of fungal natural products has been known for centuries, and millions of patients worldwide have been treated with fungal-derived small molecule drugs every year. Fungal-derived small molecule drugs are very valuable, both in terms of market prospects and humanitarian perspectives. This review summarizes the clinical application of fungal natural products, and the development of statins reveals that fungal-derived natural products are an important source of inspiration for drug synthesis in the 21st century. This review covers small molecules of fungal-derived drugs, including natural drugs, related derivatives, and structurally modified drugs. |
| |
| Keywords: | Fungal Natural products Pharmaceuticals |
|
| 点击此处可从《微生物学通报》浏览原始摘要信息 |
| 点击此处可从《微生物学通报》下载免费的PDF全文 |
|
