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A novel irinotecan derivative ZBH-1207 with different anti-tumor mechanism from CPT-11 against colon cancer cells |
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| Authors: | Zhao Dawei Wu Di Zhang Gengyue Li Yongqi Shi Weiguo Zhong Bohua Yu Hong |
| Affiliation: | 1.Department of Breast Tumor, Jilin Cancer Hospital, No.1018 Hu-Guang Road, Changchun, 130012, China ;2.Tumor Center of Jilin University No.1 Hospital, No.71 Xin-Min Street, Changchun, 130021, China ;3.Cell Biology Laboratory, Jilin Province Tumor Institute, Jilin Cancer Hospital, No.1018 Hu-Guang Road, Changchun, 130012, China ;4.Institute of Pharmacology and Toxicology Academy of Military Medical Sciences, No.27 Tai-Ping Road, Beijing, 100850, China ; |
| Abstract: | Molecular Biology Reports - Irinotecan (CPT-11) is a camptothecin derivative whose potent anti-tumor activity depends on the rapid formation of an in vivo active metabolite, SN38... |
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