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Circulating expression levels of CircHIPK3 and CDR1as circular-RNAs in type 2 diabetes patients |
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| Authors: | Rezaeinejad Farzaneh Mirzaei Ali Khalvati Bahman Sabz Gholamabbas Alipoor Behnam |
| Affiliation: | 1.Department of Biochmistry, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran ;2.Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran ;3.Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran ; |
| Abstract: | Background Recent investigations suggested that deregulated levels of Circular RNAs (circRNAs) could be associated with type 2 diabetes mellitus (T2DM) pathogenesis. Accordingly, this study aimed to determine the expression levels of circulating CircHIPK3, CDR1as and their correlation with biochemical parameters in patients with T2DM, pre-diabetes and control subjects. Methods and resultsThe expression of circRNAs in peripheral blood was determined using QRT-PCR in 70 patients with T2DM, 60 pre-diabetes and in 69 age and sex matched healthy controls. Moreover, bioinformatics tools were applied to explore and predict the potential interactions between circRNAs and other non-coding RNAs (ncRNAs). Our analysis revealed that the expression level of CircHIPK3 was significantly elevated in T2DM patients compared to healthy participants (P?Conclusions The data of this study provided evidence that the expression levels of CircHIPK3, CDR1as increased in T2DM and pre-diabetes subjects, respectively. |
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