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Metformin and/or low dose radiation reduces cardiotoxicity and apoptosis induced by cyclophosphamide through SIRT-1/SOD and BAX/Bcl-2 pathways in rats |
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| Authors: | El kiki Shereen M. Omran Mervat M. Mansour Heba H. Hasan Hesham F. |
| Affiliation: | 1.Health Radiation Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority, P.O. Box 29, Nasr City, Cairo, Egypt ;2.Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt ;3.Radiation Biology Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt ; |
| Abstract: | Molecular Biology Reports - Cyclophosphamide (CP) is a nitrogen mustard alkylating agent with effective antineoplastic, immunomodulatory and immunosuppressive properties. Despite its vast... |
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