Role of Ca2+ ion on Leishmania-macrophage attachment |
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Authors: | Sujata Misra Kshudiram Naskar Dwijen Sarkar Dilip Kumar Ghosh |
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Institution: | (1) Leishmania Group, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, 700 032 Calcutta, India |
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Abstract: | Summary
Leishmania donovani, the etiological agent for the disease visceral leishmaniasis, attach themselves to the macrophages for initiation of the disease. The attachment process has been found to be regulated by Ca2+ ions. Verapamil, a Ca2+-channel blocker inhibits Leishmania-macrophage attachment. The inhibitory effect is increased with time. Nifedipine, another Ca2+-channel blocker exhibits the same effect. The attachment process is stimulated by Ca2+-ionophore alone. The inhibitory effects of the calcium channel blockers are reversed by the ionophore. |
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Keywords: | Ca2+-channel blocker verapamil macrophage nifedipine Leishmania donovani calcium ionophore |
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