Anomerization of glucose 6-phosphate. pH dependence and solvent isotope effects.期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Anomerization of glucose 6-phosphate. pH dependence and solvent isotope effects.

Authors:	K J Schray E E Howell

Institution:	Department of Chemistry and the Center for Health Sciences, Lehigh University, Bethlehem, Pennsylvania 18015 USA

Abstract:	The anomerization of α-d-glucose 6-phosphate has been examined using a spectrophotometric coupled enzyme assay. The pH-rate profile for spontaneous d-glucose 6-phosphate anomerization reveals that the d-glucose 6-phosphate dianion is the species giving rise to the much higher rate of d-glucose 6-phosphate anomerization over that of d-glucose. A deuterium solvent isotope effect of $k_{H_{2}O} k_{D_{2}O} = 1.7$ is consistent with the postulated intramolecular general-base catalysis by the phosphate.

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