Sustained orexigenic effect of Agouti related protein may be not mediated by the melanocortin 4 receptor |
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Authors: | Kim Min Seon Rossi Michela Abbott Caroline R AlAhmed Samaher H Smith David M Bloom Stephen R |
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Institution: | Department of Internal Medicine and Institute of Endocrinology, Nutrition and Metabolism, Medical Research Center, Seoul National University College of Medicine, 110-744, Seoul, South Korea. |
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Abstract: | Intracerebroventricular (ICV) injection of Agouti related protein (AgRP), an endogenous melanocortin 3 and 4 receptor (MC3/4-R) antagonist, produces a prolonged increase in food intake. To clarify the roles of the MC3-R and MC4-R in AgRP-induced hyperphagia, the feeding effect of AgRP (83-132) was compared with that of the selective MC4-R antagonist, JKC-363 (cyclic Mpr11, D-Nal14, Cys18, Asp22-NH2]-beta-MSH11-22). Single ICV administration of AgRP (83-132) increased food intake for 48 h whilst ICV JKC-363 increased food intake for 8h. An increase in body weight at 24 and 48 h was observed following AgRP (83-132) but not JKC-363 treatment. These data suggest that the sustained orexigenic action of AgRP (83-132) may not be through MC4-R antagonism. |
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