A型流感病毒NS1蛋白结构研究进展

近年来A型流感严重威胁着人类和畜禽的健康,随着研究的深入,人们已经发现A型流感病毒的NS1蛋白对病毒毒力有重要影响,是一个多功能毒力因子、宿主细胞抗病毒免疫抑制子。根据其功能的不同分为效应区和RNA结合域。目前NS1蛋白结构已经解析,使人们可以直观的认识其各个功能位点的作用机制。该文综述了NS1蛋白的结构特征、已知的功能位点及其功能,为在结构水平上研究NS1蛋白的功能提供参考。

Progresses in structure studies of influenza A virus NS1 protein

Nonstructural protein 1（NS1）have been reported as one of the major virulence factors of Influenza A virus.The protein is a small,dimeric,multi-functional protein which takes part in both protein-protein and protein-RNA interactions,and has a crucial role in the ability of the virus to evade the antiviral response of the infected cells.According to its multiple functions,NS1A protein is made up of two domains： an N-terminal RNA-binding domain（RBD）（residues 1–73） and a C-terminal effector domain（ED）（residues 84–230/237）.The structures of the two domains have been crystallized.In this review,we described the current understanding of NS1A structure and function as well as the relationship between them.