Furanofuran lignans from Vitex negundo seeds |
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| Authors: | Cheng-Jian Zheng Xiao-Peng Lan Rui-Bin Cheng Bao-Kang Huang Ting Han Qiao-Yan Zhang Hong Zhang Khalid Rahman Lu-Ping Qin |
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| Institution: | aDepartment of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China;bInstitute for Laboratory Medicine, Fuzhou General Hospital, 156 Xi’er Huan Road, Fuzhou, Fujian 350025, PR China;cDepartment of Medical Affairs, the 100th Hospital of PLA, 4 Canglangting Street, Suzhou, Jiangsu 215007, PR China;dFaculty of Science, School of Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, England, UK |
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| Abstract: | A new furanofuran lignan, vitelignin A (1), together with eight known lignan derivatives, were isolated from the seeds of Vitex negundo. Their structures were identified as (+)-4-oxo-8-hydroxy-2,6-di(3,4-methylenedioxy)phenyl-3,7-dioxabicyclo3.3.0]octane (1), 4-oxosesamin (2), (+)-sesamin (3), (+)-paulownin (4), 4-hydroxysesamin (5), 4,8-dihydroxysesamin (6), 4-oxopaulownin (7), (+)-2-(3-methoxy-4-hydroxyphenyl)-6-(3,4-methylenedioxy)phenyl-3,7-dioxabicyclo3.3.0]octane (8), and (+)-pinoresinol (9), respectively, based on extensive NMR and MS spectroscopic studies. Compounds 1, 2, and 7 showed moderate antifungal activity in vitro. |
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| Keywords: | Vitex negundo Lignans Vitelignin A Antifungal activity |
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