Flavonoids and other constituents of Hymenostegia afzelii (Caesalpiniaceae) |
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| Authors: | Angelbert Fusi Awantu Bruno Ndjakou Lenta Eric Vouffo Donfack Jean Duplex Wansi Beate Neumann Hans-Georg Stammler Diderot Tchamo Noungoue Etienne Tsamo Norbert Sewald |
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| Institution: | aDepartment of Organic Chemistry, Faculty of Science, TWAS Research Unit (TRU) of the University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon;bDepartment of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany;cDepartment of Chemistry, Higher Teachers’ Training College, University of Yaoundé 1, P.O. Box 47, Yaoundé, Cameroon;dDepartment of Chemistry, University of Douala, P.O. Box 24157 Douala, Cameroon;eInorganic and structural Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany |
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| Abstract: | Phytochemical investigation of the stem bark and leaves of Hymenostegia afzelii resulted in the isolation of three new flavonoids, named afzelin A-C (1–3), together with five known compounds: 7,6-(2″,2″-dimethylpyrano)-3,5,4′-trihydroxyflavone, apigenin, 3-O-α-l-rhamnopyranosylcincholic acid, 3-O-β-d-glucopyranosylcincholic acid, and dodecanoic acid 1,1′-(1S)-1-(hydroxymethyl)-1,2-ethanediyl] ester. The structures of 1–3 were determined by means of spectroscopic methods. Compounds 1–3 were tested in vitro for their preliminary cytotoxicity using the Artemia salina assay. |
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| Keywords: | Hymenostegia afzelii Caesalpiniaceae Flavonoids Afzelin A-C Cytotoxic activity |
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