RETRACTED ARTICLE: Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium |
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| Authors: | Jolien Suurmond Annemarie L Dorjée Mariëtte R Boon Edward F Knol Tom WJ Huizinga René EM Toes Annemie JM Schuerwegh |
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| Institution: | (1) Department of Rheumatology, Leiden University Medical Center, PO Box 9600, Albinusdreef 2, C1-R, NL-2300 RC Leiden, The Netherlands;(2) Department of Dermatology/Allergology, University Medical Center Utrecht, Heidelberglaan 100, NL-3584 CX Utrecht, The Netherlands |
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| Abstract: | Introduction Mast cells have been implicated to play a functional role in arthritis, especially in autoantibody-positive disease. Among
the cytokines involved in rheumatoid arthritis (RA), IL-17 is an important inflammatory mediator. Recent data suggest that
the synovial mast cell is a main producer of IL-17, although T cells have also been implicated as prominent IL-17 producers
as well. We aimed to identify IL-17 expression by mast cells and T cells in synovium of arthritis patients. |
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