| 婴儿围产期感染乙型肝炎病毒后各项血清学指标的动态变化 |
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| 引用本文： | 欧阳佩英,徐志一,段恕诚,H.S.Margolis,徐华芳,任世玲,朱启镕,钱水根,王采玉,张振钧.婴儿围产期感染乙型肝炎病毒后各项血清学指标的动态变化[J].病毒学报,1987(3). |
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| 作者姓名： | 欧阳佩英 徐志一 段恕诚 H.S.Margolis 徐华芳 任世玲 朱启镕 钱水根 王采玉 张振钧 |
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| 作者单位： | 上海医科大学，上海医科大学，上海医科大学，美国疾病控制中心，上海医科大学，上海医科大学，上海医科大学，上海医科大学，上海医科大学，上海医科大学 上海，上海，上海，上海，上海，上海，上海，上海，上海 |
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| 摘 要： | 本文观察了102名新生儿出生后至18月龄的HBV血清学指标的动态变化,婴儿分成乙型肝炎疫苗按种组(63人)和对照组(39人), 观察期间HBsAg始终阴性的70名婴儿,出生后6、12和18月龄的抗-HBc阳性率依次为90％、30％和4.3％;而HBsAg阳转的27名婴儿,18月龄时抗-HBc全都阳性,但仅有6名婴儿在6月龄时测出IgM抗-HBc,疫苗接种组婴儿出生后1、3、6、12和18月龄的抗-HBs阳性率,依次为28.6％、76.2％、77。8％、82.5％和82.5％;对照组婴儿18月龄时抗-HBs阳性率仅为12.8％。
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| 关 键 词： | 乙型肝炎病毒 血清学指标 围产期感染 |
THE DYNAMICS OF HEPATITIS B VIRUS ( HBV ) MARKERS IN INFANTS AFTER ACQUISITION OF HBV INFECTION IN PERINATAL PERIOD |
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| Ouyang Peiying Xu Zhiyi Duan Shucheng H.S.MargolisXu Huafang Ren Shiling Zhu Qirong Qian ShuigenWang Caiyu Zhang Zhenjun.THE DYNAMICS OF HEPATITIS B VIRUS ( HBV ) MARKERS IN INFANTS AFTER ACQUISITION OF HBV INFECTION IN PERINATAL PERIOD[J].Chinese Journal of Virology,1987(3). |
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| Authors: | Ouyang Peiying Xu Zhiyi Duan Shucheng HSMargolisXu Huafang Ren Shiling Zhu Qirong Qian ShuigenWang Caiyu Zhang Zhenjun |
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| Institution: | Ouyang Peiying Xu Zhiyi Duan Shucheng H.S.MargolisXu Huafang Ren Shiling Zhu Qirong Qian ShuigenWang Caiyu Zhang Zhenjun Department of Epidemiology,Shang hai Medical UniversityPediatric Hospital,Shanghai Medical UniversityGynecology and Obstetric Hospital,Shanghai Medical UniversityCenter for Disease Control U.S.A. |
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| Abstract: | Examinations of serial serum specimens taken from 102 infants born to HBsAg positive mother revealed that maternal- transmitted anti-HBc in 70 HBsAg negative babies at 6, 12, 18, months of age were detected in 90.0%, 30.0% and 4.3%), respectively, while this marker in 27 HBsAg positive babies at 18 months of age were all positive. The anti-HBc can be a marker of infection only after 18 months of age. Among 27 infants who were HBsAg positive within 6 months of age, IgM anti-HBc were found in 0 , 22.2%, 0 and 0 at 3, 6, 12 and 18 months of age respectively. Therefore, the IgM anti-HBc is a poor indicator of infection in babies.Eight of 14 infants ( 57. 1%) born to anti-HBe positive mothers had placental-transmitted anti-HBe within 6 months of age which turned negative at 12 months of age. of 63 infants who had received HBV vaccine, 18(28.6%) showed anti-HBs at 1 month Of age. All but HBsAg carriers had anti-HBs at 12 months after vaccination.Of 39 unvaccinated babies who had been infected with KBV, 5(12.8%) had anti-HBs at 6-18 months of age. |
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| Keywords: | Hepatitis B virus Markers Perinatal transmission |
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