Lymphatic endothelium in health and disease |
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Authors: | Giorgia Jurisic Michael Detmar |
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Institution: | (1) Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang Pauli-Strasse 10, HCI H390, CH-8093 Zurich, Switzerland |
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Abstract: | The lymphatic vascular system has an important role in the maintenance of tissue fluid pressure homeostasis, in the mediation
of the afferent immune response via recruitment of antigen-presenting cells toward draining lymph nodes, and in the intestinal
absorption of dietary lipids. Substantial progress in our understanding of the development and the molecular mechanisms controlling
the lymphatic system has been made during the last few years, based on a recent wave of discoveries of lymphatic endothelial
cell-specific markers and growth factors. This has also led to new insights into the role of lymphatic endothelium in a number
of diseases, including primary and secondary lymphedemas. The emerging role of lymphatic endothelium in the context of inflammation
indicates that therapeutics targeting the lymphatic vasculature might represent a new strategy for anti-inflammatory therapies.
Research from the authors' laboratory is supported by National Institutes of Health grant CA69184, Swiss National Fund grant
3100A0-108207, Austrian Science Foundation grant S9408-B11, Cancer League Zurich, and Commission of the European Communities
grant LSHC-CT-2005-518178 (M.D.). |
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Keywords: | Lymphangiogenesis Lymphedema Inflammation Development VEGF-C |
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