Callistephus A,a novel sesquiterpene from the Callistephus chinensis flower |
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| Institution: | 1. School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, People''s Republic of China;2. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People''s Republic of China;3. Chifeng MinYi Natural Anthocyanins Company Limited, Inner Mongolia Autonomous Region, 024000, People''s Republic of China;1. School of Pharmacy, Shihezi University, Shihezi 832002, China;2. Xinjiang Academy of Forestry, Urumqi 830000, China;3. School of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;1. Department of Chemistry, Tripura University, Suryamaninagar 799022, Tripura, India;2. NASCO AD Biotechnology Laboratory, 11 Sachtouri Str., Pireus, Greece;3. Biomedical Applications Unit, Institute of Biology, Medicinal Chemistry & Biotechnology, NHRF, 48 Vassileos Constantinou Ave., Athens, Greece;1. Jiangsu Kanion Pharmaceutical Co. Ltd., 58 South Haichang Road, Lianyungang 222001, PR China;2. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, PR China;3. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China;1. College of Resource and Environment, Yuxi Normal University, Yuxi 653100, PR China;2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China;3. College of Resources and Environment, Southwest University, Chongqing 400716, PR China |
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| Abstract: | Two new compounds callistephus A (1) and callistephus B (2) together with 4,6-dihydroxyphenyl-1-butanone-2-β-d-O-glucopyranoside (3), were isolated and purified from the Callistephus chinensis flower. Their structures were identified by the interpretation of spectroscopic data. X-ray crystallographic and analysis of quantum chemical ECD calculation were applied to determine the absolute configuration. Of them, callistephus A represents a rare sesquiterpene with new carbon skeleton and also its possible biogenesis was proposed. |
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| Keywords: | Sesquiterpene X-ray diffraction Electronic circular dichroism (ECD) |
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