The isolation of two new lanostane triterpenoid derivatives from the edible mushroom Astraeus asiaticus |
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| Institution: | 1. Natural Products Research Unit, Centre of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Khon Kaen University, Thailand;2. Division of Science, Faculty of Liberal Arts and Science, Nakhon Phanom University, Nakhon Phanom, 48000, Thailand;3. Department of Chemistry, Biology, and Marine Science, Faculty of Science, University of the Ryukyus, Okinawa, Japan;1. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan;2. Department of Geology, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan;3. Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan;4. Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan;5. Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Pakistan;6. Department of Biotechnology, Sardar Bahadur Khan Women University, Quetta, Pakistan;1. The Key Laboratory of Biomedical Engineering, Ministry of Education, Zhejiang University, Hangzhou 310027, PR China;2. Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China;1. CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Rd, Shanghai 200032, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;1. National Center of Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry, State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China;2. University of Science and Technology of China, Hefei, 230026, China;1. Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Zhejiang 318000, PR China;2. School of Life Science and Technology, Wuhan Polytechnic University, Hubei 430023, PR China;3. Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, PR China;4. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, PR China |
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| Abstract: | Two lanostane triterpenoid derivatives, astrasiaone (2), (22S, 25R, 26R)-26-methoxy-22-26-epoxylanost-8-en-3-one, and astrasiate (3), (3α, 22S, 25R)-3, 22-dihydroxylanost-8-en-26 -oate, together with six known compounds, astraodorol (1), artabotryol B (4), artabotryol C1 (5), 6-dehydrocerevisterol (6), ergosterol (7) and hypaphorine (8) were isolated from the edible mushroom Astraeus asiaticus. 3 and 4 exhibited weak cytotoxicity against KB and NCI-H187 cancer cell lines. A comparison of the structures of 2 and 3 to that of 1, 4 and 5 suggest that these two new compounds could be the intermediate form that occurs during biogenesis. |
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| Keywords: | Lanostane triterpenoid Cytotoxic activity Biogenesis |
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