Five new cucurbitane triterpenoids with cytotoxic activity from Hemsleya jinfushanensis |
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| Institution: | 1. Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China;2. Department of Medicinal Plant Shenyang Pharmaceutical University, Shenyang 110016, China;3. School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, China;4. Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Five new cucurbitane triterpenoids (hemslepenside B–E (1–3 and 5)), one new cucurbitane (16,25-O-diacetyl-cucurbitane F (4)), and six analogues (6–11) were isolated from the roots of Hemsleya jinfushanensis. The structures of 1–5 were elucidated using infrared absorption spectroscopy (IR), high resolution electrospray ionization mass spectrometry (HR-ESI-MS), and nuclear magnetic resonance spectroscopy (NMR). These five new compounds exhibited cytotoxic effects against lung adenocarcinoma (H460), colon cancer (SW620) and human prostate cancer cells (DU145), and compound 4 showed significant cytotoxic activity, with IC50 values of 0.046, 0.18 and 0.87 μg/mL. This finding suggests that cucurbitane triterpenoids isolated from H. jinfushanensis should be studied further as potential anti-cancer drugs. |
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| Keywords: | Cucurbitane triterpenoid Cytotoxic activity |
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