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Complete or partial trisomy for the long arm of chromosome 1 in patients with various hematologic malignancies |
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| Authors: | S. E. Mamaeva N. N. Mamaev N. M. Jartseva L. V. Belyaeva E. G. Scherbakova |
| Affiliation: | 1. Institute of Cytology of the Academy of Sciences of the USSR, Leningrad, USSR 2. 1st Medical Institute, Leningrad, USSR 4. Institute of Blood Transfusion, Leningrad, USSR |
| Abstract: | This study contains data obtained from a cytogenetic investigation of six patients with acute and chronic leukaemia. The karyotypes of bone marrow or blood cells of these patients showed a partial or complete trisomy for the long arm of chromosome 1. Three observations revealed a pronounced resistance of cell clones with 1q+ towards cytostatic therapy, and a comparatively short life span of patients after detection of 1q+. The importance of these changes for the role of some chromosomes and chromosome loci in leukaemogenesis is discussed. |
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