布地奈德混悬液雾化吸入辅助治疗婴幼儿毛细支气管炎的最佳剂量研究

目的:探讨不同剂量布地奈德(Budesonide,BUD)混悬液雾化吸入对于婴幼儿毛细支气管炎进行治疗的临床效果。方法:选取我院2013年6月-2014年6月间收治的120例毛细支气管炎患儿为研究对象,采用随机数字表法将患儿随机分为高剂量组(44例)、低剂量(40例)和对照组(36例)三组。对照组进行综合治疗,高剂量组和低剂量组在综合性治疗的基础上分别给予BUD混悬液1 mg/次与0.5 mg/次治疗。观察三组患儿不良反应的发生情况,并比较他们的气促缓解时间、咳嗽消失时间、哮鸣音消失时间以及住院时间是否存在差异。结果:高剂量组的气促缓解时间、咳嗽消失时间、哮鸣音消失时间以及住院时间均明显低于低剂量组和对照组,差异均有统计学意义(P0.05);低剂量组的气促缓解时间、咳嗽消失时间、哮鸣音消失时间以及住院时间明显低于对照组,差异均有统计学意义(P0.05)。高剂量组出现3例鹅口疮(6.82%),低剂量组出现2例(5.00%),两组比较,差异无统计学意义(x2=0.124,P=0.725),且经对症处理后很快治愈,三组未见其他不良反应。结论:高剂量BUD混悬液雾化吸入佐治患儿毛细支气管炎具有疗效好,成本低和安全性高的特点,但临床应注意患者不良反应的发生。

The Best Dosage of Atomization Inspiration of Budesonide Suspension in Adjuvant Treatment of Newborns with Bronchiolitis

Objective:To investigate the clinical effect of atomization inspiration of different doses of budesonide suspension(BS) in the treatment of newborns with bronchiolitis.Methods:A total of 120 cases of newborns with bronchiolitis, who were admitted to Xuzhou Children''s Hospital of Jiangsu Province from June 2013 to June 2014, were selected and randomly divided into high dosage group (n=44), low dosage group (n=40) and control group (n-36). The control group was given comprehensive therapy, on the basis of which the high dosage group and low dosage group were respectively given BS 0.1mg/every time and BS 0.05 mg/ every time.The adverse reaction of the three groups was observed and the anhelation remission time, cough disappearing time, wheezing disappearing time, hospitalization time of the three groups were compared and analyzed.Results:The anhelation remission time, cough disappearing time, wheezing disappearing time, hospitalization time of the high dosage group were significantly lower than those of the low dosage and control group, the differences were statistically significant (P<0.05); The anhelation remission time, cough disappearing time, wheezing disappearing time, hospitalization time of the low dosage group were significantly lower than those of the control group, the differences were statistically significant(P<0.05). There were 3 cases of thrush in the high dosage group(6.82%), and 2 cases, in the low dosage group (5.00%), without statistical significance (x2=0.124, P=0.725), and the patients suffering from thrush were soon cured after symptomatic treatment. There were no other adverse reactions in the three groups.Conclusion:The atomization inspiration of high doses of budesonide suspension in the treatment of newborns with bronchiolitis has the advantages of good efficacy, low cost and high safety, but the adverse reactions need to be paid more attention to in the clinical therapy.