mTOR信号通路及其在头颈肿瘤研究中的进展

哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,m TOR)在肿瘤的发生、侵袭、转移,甚至肿瘤的局部复发都起着重要的作用。头颈肿瘤作为全球最常见的癌症死亡原因之一,有多元的逐步恶化的过程。近年来研究表明m TOR信号通路的异常表达是头颈肿瘤最常见的病理改变之一,且m TOR信号通路的多种组成元件与头颈肿瘤患者的预后有明显的相关性,这不仅可为头颈肿瘤的特异性靶向治疗提供依据,而且也可为预测头颈肿瘤患者的预后提供参考。本文就m TOR信号通路及其在头颈肿瘤中的作用做一综述,旨在对m TOR信号通路和头颈肿瘤及其预后的关系有更进一步的认识。

mTOR Signaling Pathway and Its Reaearch Progress in Head and NeckSquamous Cell Carcinoma

Mammalian target of rapamycin (mTOR) play a critical role in tumor development, invasion, metastasis and even thelocal recurrence. Head and neck squamous cell carcinoma (HNSCC), a significant cause of cancer deaths worldwide, has multiple stepwisemalignant evolutions. Recent studies have found that deregulation of the mTOR signaling pathway is one of the most commonly observedpathological alterations in HNSCC, and a variety of components of the mTOR signaling pathway have a significant correlationwith patients'' prognosis of HNSCC, it not only provides the basis for the specific targeted therapy to HNSCC, but also providing a referencefor predicting the prognosis of patients with HNSCC. In this review, we summarize the mTOR pathway and the role of mTOR inHNSCC with the purpose of having a further understanding of the relationship between the mTOR signaling pathway and HNSCC and itsprognosis.