STAT蛋白在心脏疾病中作用的研究进展

细胞信号转导途径JAK-STAT通路是细胞因子由细胞膜外向细胞核内传递信号的主要途径,参与了介导细胞生长,增殖分化,炎症反应,细胞凋亡等多种病理生理过程。STAT蛋白是JAK-STAT通路的核心分子,且所有的STAT蛋白在心脏中均有表达,改变其分子结构能调节STAT蛋白的生物学活性。目前,已有大量文献报道了STAT1、STAT3在心脏疾病中的作用,缺血性心脏疾病、缺血再灌注引起心肌损伤、心肌肥大、心肌梗塞后的心脏衰竭以及缺血预/后处理介导的心脏保护作用等均与STAT蛋白密切相关。本文主要就近年来STAT蛋白在心脏疾病中作用的研究进展进行了综述。

Research Progress of the Role of STAT Proteins in the Heart Disease

Cell signal transduction pathway JAK-STAT was a major pathway in the cell by the cytokine outward nucleus transfer signal, which was involved in mediating the cell growth, proliferation and differentiation, inflammation, apoptosis. The STAT proteins were the core elements of JAK-STAT pathway, and all STAT proteins expressed in the heart, changing the molecular structure of proteins was able to adjust the biological activity of STAT. Currently, there were many reports about the roles of STAT1, STAT3 in heart disease, ischemic heart disease, ischemia-reperfusion induced myocardial injury, cardiac hypertrophy, heart failure after myocardial infarction and ischemic pre/post processing mediated cardioprotective effects, etc, were closely related to STAT proteins. This review focuses on the research progress of the role of STAT proteins in the heart disease.