TheB locus (MHC) in the chicken: Association with the fate of RSV-induced tumors |
| |
| Authors: | Walter M Collins W Elwood Briles Robert M Zsigray William R Dunlop Allan C Corbett Kathy K Clark James L Marks Timothy P McGrail |
| |
| Institution: | (1) Department of Animal Sciences, University of New Hampshire, 03824 Durham, New Hampshire;(2) Department of Microbiology, University of New Hampshire, 03824 Durham, New Hampshire;(3) Department of Biological Sciences, Northern Illinois University, 60115 DeKalb, Illinois |
| |
| Abstract: | The fate of tumors induced by Rous sarcoma virus (RSV) was determined in anF
2 population segregating at three alloantigen loci. TheF
1 resulted from crossing tumor-resistant RPRL line 61 (B
2
B
2
D
3
D
3
I
2
I
2) with tumor-susceptible RPRL line 151 (B
5
B
5
D
4
D
4
I
8
I
8). Among theF
2 segregantsB
2
B
2,B
2
B
5, andB
5
B
5, the percentage of chicks dying of terminal tumors (by 70 days post-inoculation) was 5, 26, and 93, respectively (P 0.01). NeitherD orI genotypes nor sex significantly affected tumor growth. In chickens with terminal tumors, the incidence of metastatic lesions was also significantly associated withB genotypes. Thus, the MHC chromosomal region in the chicken appears to exert a crucial role in determining the outcome of RSV-induced tumors. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
