Synthesis and testing of new modified nucleosides. |
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| Authors: | M E Jung C J Nichols O Kretschik Y Xu |
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| Affiliation: | Department of Chemistry and Biochemistry, University of California, Los Angeles 90095-1569, USA. |
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| Abstract: | New efficient routes for the high-yielding synthesis of several classes of modified nucleosides have been developed. We have prepared both the D- and L-enantiomers of the methylene-expanded oxetanocin isonucleosides 1a-c and the L-2',3'-dideoxy isonucleosides 2abc (both the oxa and thia analogues) as well as new routes for the preparation of L-ribose and 2-deoxy L-ribose 3ab and their modified nucleosides 4. |
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