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| 链霉菌KIB-H1556次级代谢产物抗植物真菌活性研究 | |
| 引用本文： | 董庭邦,王磊,桂潇,苏灿,李洁,黄胜雄,王福生. 链霉菌KIB-H1556次级代谢产物抗植物真菌活性研究[J]. 天然产物研究与开发, 2019, 0(8): 1434-1438 |
| 作者姓名： | 董庭邦 王磊 桂潇 苏灿 李洁 黄胜雄 王福生 |
| 作者单位： | 大理大学药学与化学学院;中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室 |
| 基金项目： | 国家自然科学基金(31860098) |
| 摘 要： | 对曼陀罗(Datura stramonium L.)根际链霉菌Streptomyces sp.KIB-H1556的次级代谢产物进行研究,利用硅胶柱色谱、凝胶柱色谱和半制备HPLC等分离手段对其发酵产物进行分离纯化,采用MS和NMR等波谱学手段并结合文献数据鉴定了3个单体化合物的结构,分别为:Bafilomycin D(1)、Bafilomycin B1(2)和Bafilomycin B2(3)。初步抗植物病原真菌活性筛选发现化合物2和3具有广谱抗真菌活性,尤其对玉米病原真菌的抑制活性显著,可作为玉米病原真菌病害的潜在生物防治剂。 |
| 关 键 词： | 链霉菌 次级代谢产物 大环内酯类 抗真菌活性 |
Metabolites against plant pathogenic fungi from Streptomyces sp.KIB-H1556 |
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| DONG Ting-bang,WANG Lei,GUI Xiao,SU Can,LI Jie,HUANG Sheng-xiong,WANG Fu-sheng. Metabolites against plant pathogenic fungi from Streptomyces sp.KIB-H1556[J]. Natural Product Research and Development, 2019, 0(8): 1434-1438 | |
| Authors: | DONG Ting-bang WANG Lei GUI Xiao SU Can LI Jie HUANG Sheng-xiong WANG Fu-sheng |
| Affiliation: | (College of Pharmacy and Chemistry,Dali University,Dali 671000 ,China;State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Instituteof Botany,Chinese Academy of Sciences,Kunming 650201 ,China) |
| Abstract: | The secondary metabolites of Streptomyces sp.KIB-H1556 that an actinomycetes isolated from the rhizosphere soil of Datura stramonium L.were investigated.The extracts were purified by silica gel column,Sephadex LH-20 chromatography and semi-preparative HPLC.The structures of compounds were elucidated by NMR and mass spectrometry,and comparison with the reported data.Three compounds were identified as Bafilomycin D (1 ),Bafilomycin B1 (2 ) and Bafilomycin B2 (3 ).The antifungal assays demonstrated that compounds2 and3 possessed broad-spectrum antifungal activities against pathogenic fungi,especially pathogenic fungi related to corn.This result suggests that bafilomycins can been developed as potential antifungal agent for corn. |
| Keywords: | Streptomyces secondary metabolites macrolides antifungal activity |
| 本文献已被 CNKI 维普 等数据库收录！ | |