当药黄素抗抑郁作用研究

研究当药黄素的抗抑郁作用及其可能的作用机制。研究采用动物行为绝望模型评价当药黄素抗抑郁活性;采用药物交互作用模型探讨其主要作用环节及其可能的作用机制。结果显示当药黄素没有中枢神经兴奋性,能缩短小鼠悬尾和强迫游泳的不动时间;增加5-HTP诱导的小鼠甩头次数,可拮抗利血平引起的小鼠体温下降和眼睑下垂,对育亨宾毒性具有增强作用,但对盐酸色胺所致大鼠惊厥无影响。上述结果表明当药黄素具有抗抑郁活性,其抗抑郁活性可能与抑制5-羟色胺重摄取、增强脑内神经递5-HT神经功能和影响去甲肾上腺素有关;而与抑制体内单胺氧化酶活性无关。

Study on anti-depressive effect and mechanism of swertisin

This study evaluated the antidepressant effect and mechanism of swertisin by the behavioral and drug-imduced depression models in mice.The results showed thatswertisin had no excitatory effect on central nervous system,while significantly shortened the immobility times in tail suspension and forced swimming tests,increasedthe head-twitch number induced by 5-HTP,antagonized reserpine induced temperature decrease and blepharoptosis,andenhancde the mortality by yohimbin in mice.But it had no effect on tryptamine hydrochloride induced convulsion in rats.These studies suggested that the antidepressant activity of swertisin was exerted probably through inhibition of 5-serotonin reuptake,enhancement of neural functions of brain neurotransmitter 5-HT and,norepinephrine while was not relatedwith the inhibition of monoamine oxidase activity.