肿瘤基因治疗的研究进展

肿瘤是严重影响人类身体健康的重大疾病之一,肿瘤的发生发展是一个复杂的涉及到众多基因的过程,肿瘤的基因治疗也已经成为肿瘤治疗的研究热点之一。目前,肿瘤基因治疗的策略主要包括以下几个方面:基因沉默治疗、抑癌基因治疗、免疫基因治疗、自杀基因疗法、抑制肿瘤血管生成基因治疗、肿瘤多药耐药基因治疗、抗端粒酶疗法和多基因联合疗法等。我们简要地对上述策略及相关研究进展进行综述。

Research Development of Cancer Gene Therapy

Cancer is one of most devastating diseases that threaten human health.Cancer development and progression are complicate progress involving multiple genes.Cancer gene therapy has become one of hot spots of cancer therapy.To date,strategies of cancer gene therapy can be divided into eight main categories: gene silence therapy,tumor suppress gene therapy,immune gene therapy,suicide gene therapy,anti-angiogenesis gene therapy,mul tiple drug resistance gene therapy,anti-telomerase gene therapy and multi-genes combined therapy.In this review we introduced these strategies and relevant research development.