Identification of putative regulatory upstream ORFs in the yeast genome using heuristics and evolutionary conservation |
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| Authors: | Marija Cvijović Daniel Dalevi Elizabeth Bilsland Graham JL Kemp Per Sunnerhagen |
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| Affiliation: | (1) Department of Cell and Molecular Biology, Lundberg Laboratory, Gteborg University, PO Box 462, SE-405 30 Gteborg, Sweden;(2) Department of Computer Science and Engineering, Chalmers University of Technology, SE-412 96 Gteborg, Sweden;(3) Max-Planck Institute for Molecular Genetics, Ihnestrae 63, D-14195 Berlin, Germany;(4) Biochemistry Department, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK |
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| Abstract: | ![]()
Background The translational efficiency of an mRNA can be modulated by upstream open reading frames (uORFs) present in certain genes. A uORF can attenuate translation of the main ORF by interfering with translational reinitiation at the main start codon. uORFs also occur by chance in the genome, in which case they do not have a regulatory role. Since the sequence determinants for functional uORFs are not understood, it is difficult to discriminate functional from spurious uORFs by sequence analysis. |
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