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Orthogonal projections to latent structures as a strategy for microarray data normalization |
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| Authors: | Max Bylesjö Daniel Eriksson Andreas Sjödin Stefan Jansson Thomas Moritz Johan Trygg |
| Institution: | 1.Research group for Chemometrics, Department of Chemistry,Ume? University,Ume?,Sweden;2.Ume? Plant Science Centre, Department of Forest Genetics and Plant Physiology,Swedish University of Agricultural Sciences,Ume?,Sweden;3.Ume? Plant Science Centre, Department of Plant Physiology,Ume? University,Ume?,Sweden |
| Abstract: | BackgroundDuring generation of microarray data, various forms of systematic biases are frequently introduced which limits accuracy and precision of the results. In order to properly estimate biological effects, these biases must be identified and discarded. |
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