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Cytogenetic study in spermatocytes of mice and Chinese hamsters after treatment with isoniazid (INH) |
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| Authors: | I. -D. Adler A. Schmaltz R. Rathenberg D. Müller F. F. Strasser R. Perret |
| Affiliation: | (1) Abteilung für Genetik, Gesellschaft für Strahlen-und Umweltforschung, Laboratory I, Institut für Biologie, D-8032 Neuherberg bei München, Federal Republic of Germany;(2) Laboratory II, Institut für Anthropologie und Humangenetik der Universität Heidelberg, D-6900 Heidelberg, Federal Republic of Germany;(3) Division Pharma, Ciba-Geigy A.G., Laboratory III, Basel, Switzerland;(4) Biological Research Laboratories of the Pharmaceuticals Division of Ciba-Geigy Limited, Basle, Switzerland |
| Abstract: | Summary Meiotic chromosomes of spermatocytes from INH-treated male mice and Chinese hamsters were analysed for chromosome aberrations in diakinesis-metaphase I and metaphase II. The experiments were performed in two laboratories while a third laboratory participated in the chromosome evaluation. No enhancement of chromosome aberrations could be observed after acute treatment of early primary spermatocytes or chronic treatment of spermatogonia with INH. |
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