An antibacterial cytochalasin derivative from the marine-derived fungus Diaporthaceae sp. PSU-SP2/4 |
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| Institution: | 1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;2. Department of Microbiology and Natural Products Research Center of Excellence, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;3. National Center for Genetic Engineering and Biotechnology, Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand;1. Dept. Farmacología, Facultad de Veterinaria, 27002 Lugo, Spain;2. Dept. Fisiología, Facultad de Veterinaria, 27002 Lugo, Spain;1. Department of Biotechnology, Cochin University of Science and Technology, Cochin, 682 022, Kerala, India;2. Department of Biotechnology, MES College Marampally, Aluva, 683 107, Kerala, India;3. Department of Marine Biology, Microbiology and Biochemistry, Cochin University of Science and Technology, Cochin, 682 016, Kerala, India;4. P.G. and Research Department of Botany, St. Peter’s College, Kolenchery, 682311, Kerala, India;5. Department of Biotechnology, Calicut University, Malappuram, 673 635, Kerala, India;1. Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;2. Department of Pharmacognosy, Faculty of Pharmacy, Sana’a University, P.O. Box 33039, Sana’a, Yemen;3. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt;4. Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt;5. Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium;1. Department of Phytochemistry, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Krakow, Poland;2. Institute of Evolution, University of Haifa, Mt. Carmel, 31905 Haifa, Israel;1. Center for Natural Products Research, Chengdu Institute of Biology of the Chinese Academy of Sciences, Chengdu 610041, People''s Republic of China;2. University of the Chinese Academy of Sciences, Beijing 10049, People''s Republic of China |
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| Abstract: | A new pentacyclic cytochalasin (diaporthalasin, 1) and a new ethyl trihydroxytridecatrienoate (diaporthacol, 2) together with five known compounds, R-mevalonolactone (4), dothiorelone C (5), (4S,7S,13S)-4,7-dihydroxy-1,3-tetradeca-1,5-dienolide (6), 4β-acetoxy-9β,10β,15α-trihydroxyprobotrydial (7) and O-methyldihydrobotrydial (8) were isolated from the marine-derived fungus Diaporthaceae sp. PSU-SP2/4. The structures were established by spectroscopic techniques. Compound 1 displayed significant antibacterial activity against both Staphylococcus aureus and methicillin-resistant S. aureus with equal MIC values of 2 μg/mL. |
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| Keywords: | Diaporthaceae sp Marine-derived fungus Pentacyclic cytochalasin Ethyl trihydroxytridecatrienoate Antibacterial activity |
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