Antiproliferative metabolites from the endophytic fungus Penicillium sp. FJ-1 isolated from a mangrove Avicennia marina |
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| Institution: | 1. Department of Reparative and Reconstructive Surgery, Linyi People''s Hospital, Linyi 276003, Shandong, China;2. Department of Traditional Chinese Medicine, Linyi People''s Hospital, Linyi 276003, Shandong, China;3. Department of Stomatology, Linyi People''s Hospital, Linyi 276003, Shandong, China;1. Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Napoli, Italy;2. Dipartimento di Agraria, Sezione di Patologia vegetale ed Entomologia, Università degli Studi di Sassari, Sassari, Italy;1. Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China;2. Pharmaceutical Engineering Department, School of Biological Science and Technology, University of Jinan, Jinan 250022, PR China;3. Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China;1. Center for Natural Products Research, Chengdu Institute of Biology of the Chinese Academy of Sciences, Chengdu 610041, People''s Republic of China;2. University of the Chinese Academy of Sciences, Beijing 10049, People''s Republic of China;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China;2. Life Science College, Southwest Forestry University, Kunming 650224, China;3. University of Chinese Academy of Sciences, Beijing 100049, China;1. Nucleus of Bioassays, Biosynthesis and Ecophysiology of Natural Products (NuBBE), Department of Organic Chemistry, Institute of Chemistry, São Paulo State University, 14800-900 Araraquara, SP, Brazil;2. Faculty of Science and Technology, Federal University of Grande Dourados, 79804-970 Dourados, MS, Brazil;3. Department of Organic Chemistry, Institute of Chemistry, São Paulo State University, 14800-900 Araraquara, SP, Brazil;4. Physiology and Plant Biochemistry Section, Botanical Institute, 01061-970 São Paulo, SP, Brazil;5. Department of Biophysics and Physiology, Federal University of Piauí, 64049-550 Teresina, PI, Brazil;6. Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil |
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| Abstract: | Two new compounds, named as 4-(2′,3′-dihydroxy-3′-methyl-butanoxy)-phenethanol (1), and 15-hydroxy-6α,12-epoxy-7β,10αH,11βH-spiroax-4-ene-12-one (2), were isolated from the endophytic fungus Penicillium sp.FJ-1 of Avicennia marina. Their structures were elucidated on the basis of spectroscopic analysis. Additionally, compounds 1 and 2 exhibited antiproliferative activities, and compound 2 significantly inhibited the tumor growth of human xenograft osteosarcoma in nude mice. |
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| Keywords: | Endophytic fungus Anti-tumoral activities Nude mice |
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