Expression pattern of the homeotic gene Bapx1 during early chick gastrointestinal tract development |
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| Institution: | 1. Division of Pediatric Genetics, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey;2. Department of Medical Genetics, Hacettepe University Faculty of Medicine, Ankara, Turkey;3. Department of Bioinformatics, Institute of Health Sciences, Hacettepe University, Ankara, Turkey;4. Department of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey;5. Department of Pediatric Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey;6. Division of Neonatalogy, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey;7. Division of Neonatalogy, Department of Pediatrics, Acıbadem University Faculty of Medicine, Istanbul, Turkey;8. Department of Radiology, Tokyo Metropolitan Children''s Medical Center, Tokyo, Japan;1. Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;2. Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Shido, Sanuki, Kagawa 769-2193, Japan;3. Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan |
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| Abstract: | Regulation of the Bone Morphogenetic Protein (BMP) signaling pathway is essential for the normal development of vertebrate gastrointestinal (GI) tract, but also for the differentiation of the digestive mesenchymal layer into smooth muscles and submucosal layer. Different studies demonstrated that Bapx1 (for bagpipe homeobox homolog 1) negatively regulates the BMP pathway, but its precise expression pattern during the development and the differentiation of the GI tract mesenchyme actually remains to be examined. Here, we present the spatio-temporal expression profile of Bapx1 in the chick GI tract. We show that Bapx1 is first expressed in the undifferentiated mesenchyme of the gizzard and the colon. After the differentiation of the digestive mesenchyme, we found Bapx1 strongly expressed in the gizzard smooth muscle and in the submucosa layer of the colon. This expression pattern provides new insights into the roles of Bapx1 during the regionalization of the GI tract and the differentiation of the digestive mesenchyme of the colon and the stomach. |
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| Keywords: | BMP pathway Gastrointestinal tract Smooth muscle Chick development |
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