The identification of disease-induced biomarkers in the urine of BSE infected cattle |
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| Authors: | Sharon LR Simon Lise Lamoureux Margot Plews Michael Stobart Jillian LeMaistre Ute Ziegler Catherine Graham Stefanie Czub Martin Groschup J David Knox |
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| Affiliation: | (1) Prion Diseases Program, Public Health Agency of Canada, Winnipeg, R3E 3P6, Canada;(2) Department of Medical Microbiology, University of Manitoba, Winnipeg, R3E 0W3, Canada;(3) Department of Pharmacology, University of Manitoba, Winnipeg, R2H 2A6, Canada;(4) Institute for Novel and Emerging Infectious Diseases at the Friedrich-Loeffler Institut, 17493 Greifswald-Insel Riems, Germany;(5) Canadian Food Inspection Agency, Animal Diseases Research Institute, Lethbridge, T1J 3Z4, Canada |
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| Abstract: | Background The bovine spongiform encephalopathy (BSE) epidemic and the emergence of a new human variant of Creutzfeldt-Jakob Disease (vCJD) have led to profound changes in the production and trade of agricultural goods. The rapid tests currently approved for BSE monitoring in slaughtered cattle are all based on the detection of the disease related isoform of the prion protein, PrPd, in brain tissue and consequently are only suitable for post-mortem diagnosis. Objectives: In instances such as assessing the health of breeding stock for export purposes where post-mortem testing is not an option, there is a demand for an ante-mortem test based on a matrix or body fluid that would permit easy access and repeated sampling. Urine and urine based analyses would meet these requirements. |
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