The virion host shutoff protein of herpes simplex virus type 1 has RNA degradation activity in primary neurons |
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| Authors: | Strand Stephanie S Vanheyningen Tambryn K Leib David A |
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| Affiliation: | Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA. |
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| Abstract: | The virion host shutoff protein (Vhs) of herpes simplex virus type 1 induces destabilization of mRNA following infection. Our study of primary neurons from CD-1 mice demonstrates that vhs is functional in neurons but that more Vhs is required to mediate RNA degradation in neurons than in other susceptible cells. |
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