Comparison of the gene expression profile of undifferentiated human embryonic stem cell lines and differentiating embryoid bodies期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Comparison of the gene expression profile of undifferentiated human embryonic stem cell lines and differentiating embryoid bodies

Authors:	Bhaskar?Bhattacharya,Jingli?Cai,Youngquan?Luo,Takumi?Miura,Josef?Mejido,Sandii?N?Brimble,Xianmin?Zeng,Thomas?C?Schulz,Mahendra?S?Rao,Raj?K?Puri author-information" > author-information__contact u-icon-before" > mailto:puri@cber.fda.gov" title=" puri@cber.fda.gov" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA;(2) Laboratory of Neuroscience, National Institute on Aging, Baltimore, Maryland 21224, USA;(3) Bresagen Inc, Athens, GA, USA;(4) National Institute of Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA

Abstract:	Background The identification of molecular pathways of differentiation of embryonic stem cells (hESC) is critical for the development of stem cell based medical therapies. In order to identify biomarkers and potential regulators of the process of differentiation, a high quality microarray containing 16,659 seventy base pair oligonucleotides was used to compare gene expression profiles of undifferentiated hESC lines and differentiating embryoid bodies.

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