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Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family
Authors:Emily Steed  Nelio TL Rodrigues  Maria S Balda and Karl Matter
Institution:(1) Department of Cell Biology, UCL Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
Abstract:

Background  

Tight junctions are an intercellular adhesion complex of epithelial and endothelial cells, and form a paracellular barrier that restricts the diffusion of solutes on the basis of size and charge. Tight junctions are formed by multiprotein complexes containing cytosolic and transmembrane proteins. How these components work together to form functional tight junctions is still not well understood and will require a complete understanding of the molecular composition of the junction.
Keywords:
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