H2AX: functional roles and potential applications |
| |
| Authors: | Jennifer S Dickey Christophe E Redon Asako J Nakamura Brandon J Baird Olga A Sedelnikova William M Bonner |
| |
| Institution: | (1) Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;(2) National Cancer Institute, Building 37, Room 5050A, 9000 Rockville Pike, Bethesda, MD 20892, USA |
| |
| Abstract: | Upon DNA double-strand break (DSB) induction in mammals, the histone H2A variant, H2AX, becomes rapidly phosphorylated at
serine 139. This modified form, termed γ-H2AX, is easily identified with antibodies and serves as a sensitive indicator of
DNA DSB formation. This review focuses on the potential clinical applications of γ-H2AX detection in cancer and in response
to other cellular stresses. In addition, the role of H2AX in homeostasis and disease will be discussed. Recent work indicates
that γ-H2AX detection may become a powerful tool for monitoring genotoxic events associated with cancer development and tumor
progression. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
