Locked Nucleic Acids: Promising Nucleic Acid Analogs for Therapeutic Applications |
| |
| Authors: | Rakesh N. Veedu Jesper Wengel |
| |
| Affiliation: | Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230 Odense M |
| |
| Abstract: | Locked Nucleic Acid (LNA) is a unique nucleic‐acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid‐based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides for controlling gene expression. |
| |
| Keywords: | Locked nucleic acids (LNA) Nucleic acids RNA Aptamers |
|
