A New Quinolone and Other Constituents from the Fruits of Tetradium ruticarpum: Effects on Neutrophil Pro‐Inflammatory Responses |
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| Authors: | Tzu‐Ying Wang Jin‐Bin Wu Tsong‐Long Hwang Yueh‐Hsiung Kuo Jih‐Jung Chen |
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| Institution: | 1. Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University, Taichung 404, Taiwan;2. Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan;3. Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, Taichung 404, Taiwan;4. Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan, (phone: +886‐8‐7624002 (ext. 2827);5. fax: +886‐8‐7625308) |
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| Abstract: | The fruit of Tetradium ruticarpum is widely used in healthcare products for the improvement of blood circulation, headache, abdominal pain, amenorrhea, chill limbs, migraine, and nausea. A new quinolone, 2‐(6Z,9Z)‐pentadeca‐6,9‐dienyl]quinolin‐4(1H)‐one ( 1 ), has been isolated from the fruits of T. ruticarpum, together with eleven known compounds. The structure of the new compound was determined by NMR and MS analyses. Rutaecarpine ( 4 ), evodiamine ( 5 ), and skimmianine ( 7 ) exhibited inhibition (IC50≤20.9 μM ) of O$\rm{{_{2}^{{^\cdot} -}}}$ generation by human neutrophils in response to N‐formyl‐L ‐methionyl‐L ‐leucyl‐L ‐phenylalanine/cytochalasin B (fMLP/CB). In addition, 1 , evocarpine ( 2 ), 4, 7 , and evodol ( 8 ) inhibited fMLP/CB‐induced elastase release with IC50 values ≤14.4 μM . |
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| Keywords: | Tetradium ruticarpum Quinolones Neutrophils Pro‐inflammatory responses Elastase release |
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