Terpenes from the Soft Corals Litophyton arboreum and Sarcophyton ehrenbergi |
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| Authors: | Kamel H. Shaker Michael Müller M. Abdel Ghani Hans‐Martin Dahse Karlheinz Seifert |
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| Affiliation: | 1. Lehrstuhl für Organische Chemie, NW II, Universit?t Bayreuth, D‐95440 Bayreuth, (phone: +49‐921‐553396;2. fax: +49‐921‐555358);3. Environmental Research, Red Sea Protectorates, Egypt;4. Leibniz‐Institut für Naturstoff‐Forschung und Infektionsbiologie e.V., Hans‐Kn?ll‐Institut, Beutenbergstr. 11?a, D‐07745 Jena |
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| Abstract: | The new cembrane diterpene (3E,11E)‐cembra‐3,8(19),11,15‐tetraene‐7α‐ol ( 1 ), nephthenol ( 2 ), and all‐trans‐peridinin ( 3 ) have been isolated from the soft coral Litophyton arboreum. The tetraterpene 3 , (+)‐7,8‐epoxy‐7,8‐dihydrocembrene C ( 4 ), emblide ( 5 ), sarcophytoxide ( 6 ), sarcoglaucol‐16‐one ( 7 ), guajacophine ( 8 ), and 1,4‐peroxymuurol‐5‐ene ( 9 ) have been obtained from the soft coral Sarcophyton ehrenbergi. The compounds were characterized primarily by NMR spectroscopy. Some of the terpenes were tested for their antiproliferative activity against the cell lines HUVEC and K‐562 and for cytotoxicity against the cell line HeLa, and they showed moderate activities. |
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| Keywords: | Litophyton arboreum Sarcophyton ehrenbergi Soft corals Terpenes Cembranoids Sesquiterpenes Cytotoxic activity |
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