| 线粒体与肿瘤发生发展 |
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| 引用本文： | 冯浩,张箴,沙保勇,高兴春.线粒体与肿瘤发生发展[J].生命科学,2014(8):799-803. |
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| 作者姓名： | 冯浩 张箴 沙保勇 高兴春 |
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| 作者单位： | 西安医学院基础医学研究所,西安710021 |
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| 基金项目： | 国家自然科学基金项目（81301040）;陕西省卫生厅科研基金项目（2014D21）;西安医学院细胞生物学校级重点学科 |
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| 摘 要： | 肿瘤的发生发展是一个十分复杂的生物学过程。随着研究的深入,人们逐渐认识到线粒体不仅是重要的细胞器,而且在肿瘤的发生发展中也起着重要的作用,与肿瘤的能量代谢异常、活性氧自由基升高、组织浸润和转移能力、细胞死亡抵抗等密切相关。就近年来线粒体与肿瘤发生发展的关系研究做一综述。
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| 关 键 词： | 线粒体 能量代谢 氧自由基 肿瘤发生发展 细胞死亡调控 |
Mitochondria and tumor development |
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| FENG Hao,ZHANG Zhen,SHA Bao-Yong,GAO Xing-Chun.Mitochondria and tumor development[J].Chinese Bulletin of Life Sciences,2014(8):799-803. |
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| Authors: | FENG Hao ZHANG Zhen SHA Bao-Yong GAO Xing-Chun |
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| Institution: | ＊ (Institute of Basic Medical Science, Xi＇an Medical University, Xi＇an 710021, China) |
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| Abstract: | Tumor development is an extremely complicated biological process. With further research, it is gradually recognized that mitochondria play an essential role in tumor development not just important organelles. Mitochondria are highly dynamic organelles, which are related to the following characteristics such as abnormal energy metabolism of tumor, increasing of reactive oxygen species, ability of tissue invasion and metastasis and resistance to cell death. This paper reviews the relationship between mitochondria and tumor development. |
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| Keywords: | mitochondria energy metabolism ROS tumor development cell death regulation |
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